Table 1.
Targets and functions of important miRNAs associated with ovarian cancer.
| miRNA | Target | Alteration | Cellular function | Ref. |
|---|---|---|---|---|
| miR-214 | Sema 4D (Semaphoring 4D) | Upregulation | Inhibits cell proliferation and promotes apoptosis | [137] |
| LHX6 (LIM Homeobox 6) | Downregulation | Induces apoptosis | [138] | |
| PETN (phosphatase and tensin homolog) | Upregulation | Promotes radioresistance | [139] | |
| miR-182 | BNIP3 (BCL2 interacting protein 3) | Upregulation | Inhibits proliferation and migration | [140] |
| miR-23b | CCNG1 (cyclin G1) | Upregulation | Inhibits ovarian cancer tumorigenesis and progression | [141] |
| miR-381 | YY1 (the ubiquitous transcription factor yin yang 1) | Upregulation | Inhibits ovarian cancer cell proliferation, migration, and invasion | [142] |
| miR-132 | E2F5 (transcription factor) | Upregulation | Inhibits cell migration and invasion of cancer cells | [143] |
| miR-143-3p | TAK1 (transforming growth factor-β-activated kinase 1) | Upregulation | Inhibits the proliferation, migration, and invasion of ovarian cancer cells | [144] |
| CTGF (connective tissue growth factor) | Upregulation | Inhibits ovarian cancer cells proliferation, migration, and invasion | [145] | |
| miR-145 | CCND2 & E2F3 (cyclin D2) | Upregulation | The invasion and proliferation suppressor | [146] |
| miR-34a-5p | NEAT1 (nuclear paraspeckle assembly transcript 1) | Downregulation | Suppresses Cell proliferation and triggers apoptosis | [147] |
| miR-383-5p | TRIM27 (tripartite motif containing 27) | Upregulation | Proliferation, chemosensitivity suppressor and enhancer in ovarian cancer cells | [148] |
| miR-148a-3p | c-Met (tyrosine-protein kinase Met) | Upregulation | Inhibits invasion of ovarian cancer cells and cell migration | [149] |
| miR-141 | KEAP1 (Kelch-like ECH-associated protein 1) | Upregulated | Cisplatin resistance | [150] |
| miR-218 | RUNX2 (runt-related transcription factor 2) | Upregulated | Inhibits proliferation and invasion | [151] |
| miR-199a | HIF-1α & HIF-2α (hypoxia-inducible factor) | Upregulation | Decreases migration and metastatic tumor formation | [152] |
| miR-491-5p | EGFR (epidermal growth factor receptor) and BCL-XL | Upregulation | Induces cancer cell apoptosis by blocking downstream AKT and MAPK signaling pathways | [153] |
| miR-744-5p | HNRNPC (heterogeneous nuclear ribonucleoproteins C1/C2) and NFIX (nuclear factor 1 X-type) | Upregulation | Induces tumor cell apoptosis | [154] |