Table 3.
Relative content of 14 metabolites of MC in rat plasma, bile, urine, and feces.
| Metabolite | Metabolic pathway | Relative content (%) | |||
|---|---|---|---|---|---|
| Plasma | Bile | Urine | Feces | ||
| M1 | Hydroxylation + glucuronide conjugation | 1.4 | 45.5 | 29.2 | 0.3 |
| M2 | Hydroxylation + sulfation | 6.5 | 28.2 | 29.7 | 1.0 |
| M3 | Hydroxylation | 0.3 | 0.0 | 8.3 | 11.9 |
| M4 | Glucuronide conjugation | 2.9 | 4.3 | 0.9 | 5.0 |
| M5 | Glucuronide conjugation | 4.9 | 1.8 | 0.6 | 2.4 |
| M6 | Hydroxylation | 0.0 | 0.0 | 0.0 | 4.2 |
| M7 | Glucuronide conjugation | 0.0 | 0.0 | 1.5 | 0.2 |
| M8 | 2x Hydroxylation | 0.3 | 0.0 | 1.3 | 0.2 |
| M9 | Hydroxylation + glucuronide conjugation | 0.6 | 6.0 | 12.5 | 1.6 |
| M10 | Parent | 75.8 | 11.7 | 9.1 | 57.7 |
| M11 | Hydroxylation + sulfation | 3.1 | 2.7 | 6.9 | 12.0 |
| M12 | Hydroxylation | 0.0 | 0.3 | 0.0 | 3.1 |
| M13 | 3x Hydroxylation | 0.0 | 0.0 | 0.0 | 0.3 |
| M14 | Hydration + glucuronide conjugation + 2× alcohols dehydration | 4.2 | 0.0 | 0.0 | 0.2 |