Figure 11.

Alternative use of cADPR and IP₃ as Ca²⁺ mobilizing second messengers in different types of cells/tissues and in normal and diabetic β-cells (adapted from Ref. 96). cADPR induces Ca²⁺ release from pancreatic islet microsomes but IP₃ does not.⁷⁹⁾ In cerebellum microsomes, both cADPR and IP₃ induced Ca²⁺ release.⁷⁹⁾ In rabbit small intestinal longitudinal muscle, but not circular smooth muscle, cADPR-dependent pathway participated in Ca²⁺ mobilization and muscle contraction.²⁹⁰⁾ Recently, in opossum esophagus, cADPR was found to induce the contraction of longitudinal smooth muscle, but not circular smooth muscle.²⁹¹⁾