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. 2021 Oct 11;97(8):423–461. doi: 10.2183/pjab.97.022

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© 2021 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 14. — Tissue-specific alternative splicing of RyR2 mRNA (adapted from Ref. 101). In pancreatic islet and neuro-endocrine cells, RyR2 mRNA is generated/maturated using “gt/ag” splicing. On the other hand, RyR2 mRNA is generated/maturated using not only the canonical “gt/ag” intron splicing site but also using the novel “gg/ag” site in heart and blood vessels. The exon 4 was also alternatively spliced by the “gt/ag” rule.^98,101) Therefore, the heart/blood vessel type RyR2 mRNA can contain exon 4 and exon 75.