Figure 15.

Proliferation of insulin-positive islet cells in the remaining pancreas of 90% depancreatized rats receiving daily injection of PARP inhibitor, nicotinamide (adapted from Refs. 164 and 292). A. Pancreatic tissue from 90% depancreatized rat receiving daily injection of saline. B. Pancreatic tissue from untreated control rat. C. Pancreatic tissue from 90% depancreatized rat receiving daily injection of nicotinamide. PARP inhibitor up-regulates Reg. Reg protein acts as an autocrine/paracrine growth factor for β-cell regeneration.^{156,157,164,292)}