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. 2021 Oct 11;97(8):479–498. doi: 10.2183/pjab.97.024

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© 2021 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — (Color online) NAD kinase in human, plant, yeast, and bacteria. Localization of NAD kinase (abbreviated to NADK in this figure) in human (Homo sapiens), plant (A. thaliana), yeast (S. cerevisiae), and bacteria is illustrated. Human is found to contain only one NAD kinase in cytosol. Plant A. thaliana has three kinds of NAD kinases, NADK1 in cytosol, NADK2 in chloroplast, and NADK3 in peroxisome. Yeast S. cerevisiae has three kinds of NAD kinases, Utr1 and Yef1 in cytosol and Pos5 in mitochondria. NADK3 and Pos5 show high affinity to NADH (i.e., NAD(H) kinase indicated as NAD(H)K in this figure). Bacteria have only one NAD kinase in cytosol. Note that NAD kinase in the mitochondria of the human cell is marked with a question sign, because the identification of the kinase is a direct theme of this study. Specifically, it signifies C5orf33 (i.e., ATP/poly(P)-NAD(H) kinase), as explained in Section 4.