Table 1.
Characteristics of patients who were withdrawn from antipsychotics
| Case | A | B | C | D | E | F | Inpatients | Outpatients |
|---|---|---|---|---|---|---|---|---|
| Age (yr) | 79 | 70 | 83 | 79 | 33 | 57 | 77.8 ± 4.8 | 45.0 ± 12.0 |
| Sex | M | F | F | M | M | M | NA | NA |
| Treatment setting | IN | IN | IN | IN | OUT | OUT | NA | NA |
| Onset of illness (yr) | 23 | 36 | 17 | 38 | 19 | 24 | 28.5 ± 8.8 | 21.5 ± 2.5 |
| Duration of illness (yr) | 56 | 34 | 66 | 41 | 15 | 33 | 49.3 ± 12.5 | 24.0 ± 9.0 |
| Number of psychiatric hospitalizations | 4 | 6 | 4 | 4 | 1 | 0 | 4.5 ± 0.9 | 0.5 ± 0.5 |
| Duration of current hospitalization (yr) | 14 | 5 | 7 | 6 | N.A. | N.A. | 8.0 ± 3.5 | NA |
| Duration of free from antipsychotics (yr) | 1.6 | 1.8 | 2.4 | 7.1 | 8.0 | 4.3 | 3.2 ± 2.3 | 6.1 ± 1.9 |
| Presence of physical comorbidity | Yes | Yes | Yes | Yes | No | Yes | NA | NA |
| BMI | 18.3 | 15.2 | 12.8 | 15.2 | 32.5 | 20.4 | 15.4 ± 1.9 | 26.5 ± 6.0 |
| PANSS | ||||||||
| Total | 135 | 112 | 112 | 113 | 44 | 45 | 118.0 ± 9.8 | 44.5 ± 0.5 |
| Positive symptoms | 28 | 21 | 10 | 9 | 8 | 10 | 17.0 ± 7.9 | 9.0 ± 1.0 |
| Negative symptoms | 36 | 33 | 49 | 47 | 10 | 11 | 41.3 ± 6.9 | 10.5 ± 0.5 |
| General symptomatology | 71 | 58 | 53 | 57 | 26 | 24 | 59.8 ± 6.8 | 25.0 ± 1.0 |
| SAS, total score | 7 | 29 | 15 | 20 | 0 | 0 | 17.8 ± 8.0 | 0 |
| BAS, global severity score | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| AIMS, total score of items 1–7 | 15 | 2 | 12 | 0 | 0 | 0 | 7.3 ± 6.4 | 0 |
| FACT-Sz | 15 | 10 | 5 | 9 | 65 | 60 | 9.8 ± 3.6 | 62.5 ± 2.5 |
| Barthel Index | 25 | 5 | 0 | 5 | 100 | 100 | 8.8 ± 9.6 | 100 |
| CIRS-G, total score | 16 | 17 | 14 | 15 | 2 | 12 | 15.5 ± 1.1 | 7.0 ± 5.0 |
| EQ-5D | 0.03 | 0.19 | 0.03 | 0.27 | 0.81 | 0.88 | 0.13 ± 0.11 | 0.85 ± 0.04 |
| RS, total score | N/A | N/A | N/A | N/A | 109 | 125 | N/A | 117.0 ± 8.0 |
| FACIT-Sp, Spirituality score | N/A | N/A | N/A | N/A | 20 | 17 | N/A | 18.5 ± 1.5 |
| WHOQOL | N/A | N/A | N/A | N/A | 2.7 | 3.4 | N/A | 3.1 ± 0.4 |
Values are presented as number only or mean ± standard deviation.
AIMS, Abnormal Involuntary Movement Scale; Barthel Index, Barthel Index of Activities of Daily Living; BAS, Barnes Akathisia Scale; BMI, body mass index; CIRS-G, Cumulative Illness Rating Scale for Geriatrics; EQ-5D, EuroQoL five dimensions; F, female; FACIT-Sp, The Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale; FACT-Sz, Functional Assessment for Comprehensive Treatment of Schizophrenia; IN, inpatient; M, male; MMSE, Mini Mental State Examination; NA, not applicable; N/A, not available; OUT, outpatient; PANSS, Positive and Negative Syndrome Scale; RS, Resilience Scale; SAS, Simpson-Angus Scale for Extrapyramidal Side Effects; WHOQOL, WHOQOL-BREF instrument Japanese version.