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. 2021 Nov 1;131(21):e137750. doi: 10.1172/JCI137750

Figure 8. Anti-CHI3L1 and anti–PD-1 interact to augment antitumor responses in melanoma lung metastasis.

Figure 8

WT mice were given B16-F10 melanoma cells or control vehicle and treated with control IgG, FRG, and/or anti–PD-1 antibodies, alone or in combination. Melanoma tumor burden was evaluated 2 weeks later. (A) Representative lungs from mice treated with control IgG, FRG, and/or anti–PD-1 antibodies, alone or in combination. As noted, the antibodies were given at doses of 100 μg every other day by i.p. injection from 1 day after melanoma cell challenge. (B) The number of pleural melanoma colonies was quantitated in the lungs from the mice in A. Each dot is representative of an individual animal. A is representative of at least 3 similar evaluations. The values in B represent the mean ± SEM of the evaluations represented by the individual dots in the lungs from the experiment representatively illustrated in A. ***P < 0.001, ****P < 0.0001 (1-way ANOVA with Tukey’s post hoc test).