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. 2021 Sep 1;22(11):1428–1439. doi: 10.1038/s41590-021-01028-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — (a) Age distribution of the cohort based on disease severity. Box plots with median ± minimum to maximum. (b) Correlation plots between age and nasal S-Flow anti-Spike IgG or IgA binding (%). (c) Correlation plots between age and nasopharyngeal microbiota Shannon and Simpson diversity and Staphylococcus genus abundance (%). For all plots, analytes were measured in the plasma of healthy controls (n = 12 donors), mild to moderate (n = 15 patients), severe (n = 11 patients) and critical (n = 23 patients) or in the nasopharyngeal compartment of healthy controls (n = 10 donors), mild to moderate (n = 10 patients), severe (n = 10 patients) and critical (n = 12 patients).In (b, c), σ represents Spearman coefficient and p the p value. For all panels: *P < 0.05; **P < 0.01; ***P < 0.001.