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. 2021 Sep 1;22(11):1428–1439. doi: 10.1038/s41590-021-01028-7

Fig. 4. SARS-CoV-2 antiviral immune responses are distinct locally and systemically.

Fig. 4

a, Plasma viral loads evaluated by digital PCR and in nasopharyngeal swabs estimated by RT–PCR and expressed as relative copies (cp) per ml; n = 61 (left) and n = 42 (right). b, Correlation plots between viral load the in the plasma versus nasopharyngeal compartment. c,e, MDS projection for plasma compartment (cytokines, antibodies and blood viral load; c) and nasopharyngeal compartment (cytokines, antibodies and nasal viral load; e). The dotted lines represent the most associated analytes. d,f, Individual correlation plots between viral load and cytokines or antibodies. In a, box plots show the median ± minimum to maximum values. P values were determined with the Kruskal–Wallis test followed with Dunn’s post hoc test for multiple comparisons. In b (n = 42), d (n = 61) and f (n = 42), σ represents the Spearman coefficient. *P < 0.05; **P < 0.01; ***P < 0.001.