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. 2021 Oct 28;7:141. doi: 10.1038/s41523-021-00341-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–d Heatmap displaying mRNA levels of Trop2 associated 5-gene metabolic signature (TALDO1, GPI, SHMT2, LDHA, and ADK) and known oncogenes (TAGLN2, NOLC1, HSP90AB1, HDGF, MCM5, and NCL) in breast cancer patient samples (upper panel). The red color indicates a higher z-score whereas blue represents a lower z-score. Individual gene expression levels (TALDO1, GPI, SHMT2, LDHA, and ADK) are presented as dot plots (lower panel). The mRNA levels of the identified 5-gene metabolic signature in METABRIC ⁵⁷ and TCGA (Firehose Legacy) clinical datasets are obtained from cBioPortal for Cancer Genomics (https://www.cbioportal.org/)^58,59. The mRNA levels of the identified 5-gene metabolic signature in E-MTAB-365 ⁶⁰ and GSE21653 ⁶¹ clinical datasets are shown. Error bars represent standard deviation. Adjusted P value was calculated based on Bonferroni testing in Prism software. **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns not significant.