Fig. 5. Five-gene metabolic signature predicts poor outcome in early stages of breast cancer independent of breast cancer subtypes.
a Functional network analysis and functional enrichment analysis of five metabolic proteins. Functional network analysis is performed by String (https://string-db.org/)71. b Survival curves of breast cancer patients with tumor stage 1–3 samples that are categorized into two subgroups as upper tertile (T1) and lower tertile (T3) based on the mean mRNA z-score of 5 metabolic genes per sample from the METABRIC dataset. c Survival curves of patient subgrouping based on 5-gene metabolic signature with different subtypes of breast cancer including ER+, HER2+, and TNBC from METABRIC dataset. P value of survival analysis was calculated based on Log-Rank Test in Prism software. *P < 0.05, ****P < 0.0001 and ns not significant.