Fig. 6. Five-gene metabolic signature predicts worse overall and disease-free survival in breast cancer patients.
Survival curves (overall survival or recurrence-free survival) of breast cancer patients were sorted into two subgroups as upper tertile (T1) and lower tertile (T3) based on the mean of mRNA z-score of 5 metabolic genes per sample from 12 clinical public datasets. The overall survival (OS) information of METABRIC57 and TCGA (Firehose Legacy) clinical datasets are obtained from cBioPortal for Cancer Genomics58,59. The relapse-free survival (RFS) information of all other clinical datasets is generated using Kaplan–Meier Plotter (https://kmplot.com/analysis/index.php?p=service)62. P value of survival analysis was calculated based on Log-Rank Test in Prism software. *P < 0.05, **P < 0.01, ****P < 0.0001.