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. 2021 Oct 27;7:101. doi: 10.1038/s41421-021-00343-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Heatmap of the DMRs in the F₀ generation. b Heatmap of the DMRs in the F₁ generation. c Heatmap of the DMRs in the F₂ generation. d Trend in DMRs across generations after removal of the original stimulus – psychological stress. e Distribution of the Δβ values (changes in DNA methylation levels of the DMRs) across generations. f Distribution of the stress-induced F₀ DMRs at the gene level. g Distribution of the functional genes related to DMRs. h Enrichment of F₀-DMRs related genes to the phenotype-associated genes from mouse genome information (MGI) database. i Gene Ontology (GO) analysis of genes related to F₀-DMRs. j Encyclopedia of Genes and Genomes (KEGG) pathway analysis of genes related to F₀-DMRs.