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. 2021 Oct 27;7:101. doi: 10.1038/s41421-021-00343-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a DNA methylation levels of the transgenerationally inherited DMR, Chr13:75,929,838-75,930,456, in sperm samples of all generations. b DNA methylation patterns of the transgenerationally inherited DMR in sperm samples. c DNA methylation levels of the transgenerationally inherited DMR in testis tissues. d DNA methylation patterns of the transgenerationally inherited DMR in testis tissues. e Gene expression patterns of Rhobtb3 in testis tissues. f DNA methylation levels of the intergenerationally inherited DMR, Chr10:40,640,103-40,641,054, in sperm samples of all generations. g DNA methylation patterns of the intergenerationally inherited DMR in sperm samples. h DNA methylation levels of the intergenerationally inherited DMR in brain tissues. i DNA methylation patterns of the intergenerationally inherited DMR in brain tissues. j Gene expression patterns of Ddo in brain tissues. **t-test p-value < 0.01; n.s. no significant, t-test p-value > 0.05.