Table 2:

miRNAs regulates various imperative events in inflammation by targeting critical genes involved in the pathway.

miRNA	Targets	Process	References
TLR pathway
miR-9	NF-κB1/p50	Transcription by NF-κB is decreased	[123]
miR-16	TNF-α	Decrease levels of inflammatory	[124]
miR-17–5p, 20a, 106a	Transcription factor CBF	Inhibition of monocyte maturation	[125]
miR-21	PDCD4, IL12p35	Derepression of IL-10	[126]
miR-27b	PPARγ		[127]
miR-105	TLR2		[128]
miR-106	IL-10	Cooperates with RNA binding protein	[129]
miR-125b	TNF-α	to decrease IL-10	[130]
miR-145	MAL	Impedes TLR signaling	[131]
miR-146a	TRAF6, IRAK1, IRAK2	Negative feedback regulator in TLR signaling	[132]
miR-155	AID, MyD88, TAB2, IKKԑ, SHIP1, SOCS1, C/.EBPBβ	Proinflammatory in TLR signaling	[133]
miR-199	IKKβ	TLR4/NF-κB p65/NGAL pathways	[134]
miR-221	TNF-α		[135]
miR-223	TLR3, TLR4, IKKα	Granulopoiesis and monocyte activation	[136]
Let-7i and let7e	TLR4	Downregulate inflammatory signaling	[137]
T cell development and function
miR-181a	SHP2	T cells: strength of the transduced T-cell receptor signal.	[138]
miR-155	SOCS1	miR-155-deficient mice suffer impaired survival of Treg, T regs/Th17 ratio	[139]
miR-146a	STAT1	miR-146a-deficient Treg (FoxP3) cannot inhibit hyperactive immune system. Upregulated in RA	[140]
miR-17~92 cluster	pten	immunoproliferative disorder and autoimmune disease	[141]
miR-326	Ets-1 transcription factor	autoimmune inflammation	[142]
B cells development and function
miR-181a	Lin28/Mcl-1	guided B-cell development	[143]
miR-150	c-Myb and Foxp1	B-cell development	[144]
miR-34a	c-Myb and Foxp1	B cell development	[145]
miR-155	Pu.1, SHIP1 and AID	regulate antibody secretion and class-switch recombination	[146]
miR-181b		reduce the class-switch recombination rates	[147]