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A proposed model for the role of the NR pair, PPARα-REV-ERBα, and its regulation of circadian clock genes in CLA-induced hepatic steatosis. (A) CLA-induced activating PPARα and repressive REV-ERBα transcriptional complexes, the coordinate actions of which modulate the circadian clock gene expression. (B) The regulation mechanism of PPARα in directing REV-ERBα (Nr1d1) expression via the recruitment of histone marks and cofactors at both the promoter and the enhancer.
