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. 2021 Oct 28;12(11):1013. doi: 10.1038/s41419-021-04332-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Expression of Ephexin1 mRNA in 12 primary cancer types from TCGA. Data are shown as mean ± SD. ns not significant, ^***P < 0.001, two-tailed Student’s t test. B Kaplan–Meier analysis of overall survival according to Ephexin1 in CRC and LC patients. P values are for a log-rank test. C Immunohistochemistry (IHC) staining was performed to evaluate Ephexin1 expression in CRC and LC tissues and their corresponding normal tissues. Hematoxylin is the counterstain. Scale bar = 100 μm. Data are shown as mean ± SD, P values are for a two-way ANOVA. D Ephexin1 protein expression in normal and indicated colon (n = 8) and lung (n = 11) cancer cell lines were examined by western blot. E Effect of Ephexin1 knockdown on cell proliferation by MTT assay in HCT116, H1299, H460, and A549 cells. Data are shown as mean ± SD. ^***P < 0.001, two-way ANOVA. F, G Anchorage-independent growth assessed by soft agar assay (F) and migration ability (G) determined by transwell assay in Ephexin1-depleted HCT116, H1299, H460, and A549 cells. Representative images are shown. Scale bar = 100 μm. Data are shown as mean ± SD. ^**P < 0.01, and ^***P < 0.001, two-tailed Student’s t test. H Control and Ephexin1-depleted HCT116, H1299, and H460 cells were inoculated subcutaneously in BALB/C nude mice (n = 4). Tumor volumes recoded at the indicated times are shown. Data are shown as mean ± SD. ^***P < 0.001, two-way ANOVA. I Average tumor weight of each group at the endpoint of the experiment are shown. Data are shown as mean ± SD. ^*P < 0.05 and ^**P < 0.01, two-tailed Student’s t test.