Table 2.
Biomarkers | N | Model 1* | Model 2† | Model 3‡ |
---|---|---|---|---|
UA, μmol/L | ||||
T1 (125–218) | 349 | Reference | Reference | Reference |
T2 (219–256) | 347 | 1.81 (0.31, 3.31)§ | 1.54 (0.06, 3.03)§ | 1.22 (-0.27, 2.71) |
T3 (257–430) | 345 | 5.29 (3.78, 6.80)∥ | 3.75 (2.24, 5.27)∥ | 3.15 (1.63, 4.68)∥ |
eGFR, mL/min/1.73 m 2 | ||||
T1 (68–109) | 366 | 3.07 (1.5, 4.64)∥ | 0.87 (−0.75, 2.49) | 0.25 (−1.35, 1.86) |
T2 (110–118) | 321 | 1.65 (0.02, 3.28)§ | 0.29 (−1.31, 1.89) | −0.08 (−1.66, 1.51) |
T3 (119–137) | 354 | Reference | Reference | Reference |
GGT, U/L | ||||
T1 (4–10) | 336 | Reference | Reference | Reference |
T2 (11–15) | 375 | 1.85 (0.27, 3.42)§ | 1.15 (−0.35, 2.66) | 0.69 (−0.84, 2.22) |
T3 (16–68) | 330 | 4.72 (3.10, 6.34)∥ | 3.11 (1.56, 4.67)∥ | 2.04 (0.31, 3.76)§ |
ALP, U/L | ||||
T1 (18–43) | 341 | Reference | Reference | Reference |
T2 (44–52) | 332 | 1.92 (0.31, 3.53)§ | 1.57 (0.06, 3.08)§ | 1.16 (−0.34, 2.67) |
T3 (53–193) | 368 | 4.83 (3.26, 6.40)∥ | 3.2 (1.69, 4.71)∥ | 2.32 (0.78, 3.86)∥ |
LDH, U/L | ||||
T1 (97–139) | 333 | Reference | Reference | Reference |
T2 (140–157) | 353 | −0.13 (−1.74, 1.48) | −0.02 (−1.52, 1.48) | −0.38 (−1.87, 1.10) |
T3 (158–273) | 355 | 3.08 (1.47, 4.69)∥ | 2.44 (0.94, 3.94)∥ | 1.48 (−0.08, 3.27) |
AST/ALT | ||||
T1 (0.38–0.97) | 340 | 3.36 (1.75, 4.97)∥ | 1.68 (0.11, 3.25)§ | 0.09 (−1.62, 1.79) |
T2 (1.00–1.29) | 355 | 2.80 (1.21, 4.39)∥ | 1.49 (−0.03, 3.00) | 0.76 (−0.78, 2.30) |
T3 (1.30–3.40) | 346 | Reference | Reference | Reference |
Results were regression coefficients (95% confidence interval) of linear mixed-effects regression models. UA, uric acid; eGFR, estimated glomerular filtration rate; GGT, gamma–glutamyl transpeptidase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; AST/ALT, aspartate aminotransferase to alanine aminotransferase ratio; T, tertile.
Model 1 was adjusted for gestational age (linear and quadratic terms).
Model 2 was adjusted for gestational age (linear and quadratic terms), pre-pregnancy BMI, maternal age, monthly per capita income, education level, nulliparous, folic acid supplement intake during pregnancy, family history of hypertension, family history of diabetes mellitus, smoking and alcohol consumption.
Model 3 included all six biomarkers simultaneously and was adjusted for gestational age (linear and quadratic terms), pre-pregnancy BMI, maternal age, monthly per capita income, education level, nulliparous, folic acid supplement intake during pregnancy, family history of hypertension, family history of diabetes mellitus, smoking and alcohol consumption.
P < 0.05.
P < 0.01.