FIGURE 1.

SchB effectively improved the abnormal body weight and food intake of SD rats induced by THP. (A) From the third week, the body weight of rats injected with THP alone was significantly lower than that of normal rats (THP vs. CON, p < 0.05). The weight loss of THP rats was further reduced after 4 weeks (p < 0.01, THP vs. CON). In THP rats treated with SchB (50 mg*kg⁻¹), weight loss was significantly improved (p < 0.05, SchB + THP vs. THP). The improvement was more significant after the fifth week (p < 0.01, SchB + THP vs. THP). (B) From the fourth week, the food intake of rats injected with THP alone was significantly lower than that of normal rats (THP group vs. CON group, p < 0.05). The food intake of THP rats decreased further after 6 weeks (p < 0.01, THP and CON). In THP rats treated with SchB (50 mg*kg⁻¹), the food intake increased significantly (p < 0.05, SchB + THP vs. THP). The improvement was more significant after the seventh week (p < 0.01, SchB + THP vs. THP). All values are mean ± SD. ^* p < 0.05 vs. CON, ^** p < 0.01 vs. CON; ^# p < 0.05 vs. THP, and ^## p < 0.01 vs. THP.