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. 2021 Oct 15;12:733805. doi: 10.3389/fphar.2021.733805

FIGURE 3.

FIGURE 3

SchB attenuated THP-induced cardiac histopathological changes, apoptosis, and increased CWI. The myocardial tissue structure of the CON and SchB group was normal. In the THP group, the arrangement of cardiomyocytes was disordered, the intercellular space was significantly increased, and the cardiomyocytes were focal vacuolization or steatosis. The vacuolation and steatosis of myocardial cells in rats treated with SchB were significantly improved. TUNEL staining showed that there was no apoptosis in the control group and SchB group. In the THP group, there was partial apoptosis. In the group of SchB + THP, a few or a single cell apoptosis was occasionally observed. The CWI of rats in the THP group was significantly higher than that in the normal group, and the CWI of rats in the SchB + THP group was significantly lower than that in the THP group. All values are the mean ± SD. * p < 0.05 vs. CON, ** p < 0.01 vs. CON, # p < 0.05 vs. THP, and ## p < 0.01 vs. THP.