Table 2.
Clinical and serological characteristics of patients with MDA5− dermatomyositis (DM) and others.
| Index | NXP2+ (N = 17) | TIF1γ+ (N = 23) | Mi-2α/β+ (N = 13) | SAE1+ (N = 15) | ASyS (N = 57) | RA (N = 89) | SSc (N = 30) |
|---|---|---|---|---|---|---|---|
| Sex, female, n (%) | 11 (64.71) | 10 (43.48) | 12 (92.31) | 14 (93.33) | 35 (61.40) | 70 (78.65) | 21 (70.00) |
| Age (years), mean (SD) | 48.59 (18.17) | 57.00 (9.50) | 53.77 (13.65) | 58.00 (8.20) | 53.03 (13.28) | 57.81 (11.20) | 52.10 (12.10) |
| Myositis, n (%) | 14 (82.35) | 17 (73.91) | 13 (100.00) | 8 (53.33) | 22 (38.60) | 0 (0.00) | 0 (0.00) |
| ILD, n (%) | 3 (17.65) | 1 (4.35) | 2 (15.38) | 5 (33.33) | 36 (63.16) | 11 (12.36) | 19 (63.33) |
| Fever, n (%) | 4 (23.53) | 3 (13.04) | 0 (0.00) | 0 (0.00) | 16 (28.07) | 4 (4.49) | 0 (0.00) |
| Arthralgia, n (%) | 11 (64.71) | 13 (56.52) | 8 (61.54) | 4 (26.67) | 14 (24.56) | 55 (61.80) | 2 (6.67) |
| WBC (103/µl), mean (SD) | 9.89 (4.94) | 8.82 (3.59) | 8.83 (2.75) | 7.54 (1.79) | 9.83 (4.04) | 7.18 (3.01) | 6.42 (2.70) |
| HB (g/L). mean (SD) | 111.5 (24.82) | 152.52 (28.46) | 120.00 (6.97) | 129.08 (17.65) | 136.23 (12.60) | 115.42 (24.18) | 137.79 (30.38) |
| Lymphopenia (<0.8 × 103/µl), n (%) | 4 (23.53) | 2 (8.70) | 2 (15.38) | 4 (26.67) | 11 (19.30) | 3 (3.37) | 1 (3.33) |
| PLT (103/µl), mean (SD) | 212.07 (62.60) | 244.04 (66.25) | 265.00 (64.49) | 237.25 (72.78) | 242.33 (35.02) | 296.57 (124.38) | 253.33(77.59) |
| CKmax (U/L), mean (SD) | 5,297.00 (8464.68) | 1,312.77 (2479.27) | 1,845.17 (1826.54) | 306.30 (425.30) | 1,164.82 (1904.91) | 43.72 (46.63) | 53.00 (37.22) |
| Ferritin (ng/ml), mean (SD) | 1,616.22 (1614.39) | 558.94 (578.12) | 904.54 (829.75) | 439.30 (549.87) | 487.66 (514.54) | 218.65 (243.52) | 103.69 (91.17) |
| CRP (mg/L), mean (SD) | 19.22 (38.74) | 7.84 (11.74) | 12.72 (21.38) | 2.82 (0.68) | 14.87 (19.03) | 19.30 (28.87) | 5.59 (7.49) |
| ESR (mm/h), mean (SD) | 20.79 (22.75) | 14.89 (13.36) | 24.71 (13.47) | 13.00 (10.55) | 23.85 (19.69) | 38.83 (27.67) | 15.08 (11.75) |
| IgG (g/L), mean (SD) | 10.55 (3.28) | 15.90 (3.72) | 15.33 (8.01) | 14.00 (6.06) | 14.47 (5.83) | 22.85 (55.28) | 16.36 (3.75) |
| Anti-SS-A52 (AI), n (%) | 0 (0.00) | 1 (4.35) | 0 (0.00) | 2 (13.33) | 23 (40.35) | 15 (16.85) | 0 (0.00) |
| Anti-MDA5 titer (RU/ml), mean (SD) | 18.90 (8.64) | 13.56 (5.87) | 12.10 (4.21) | 11.83 (1.31) | 16.28 (5.58) | 13.97 (6.14) | 14.50 (5.79) |
Anti-MDA5, anti-melanoma differentiation-associated gene 5; ASyS, anti-synthase syndrome; RA, rheumatoid arthritis; ILD, interstitial lung disease; WBC, white blood cell; HB, hemoglobin; PLT, platelet; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IgG, immunoglobulin G.
P-value <0.05 is statistically significant in bold text.