Table 2.
Significantly altered metabolic pathways between PCa and BPH groups with PSA levels at gray zone of 4–10 ng/ml.
| Pathway name | KEGG.id | −log(p) | Impact | Hits |
|---|---|---|---|---|
| Glycerophospholipid metabolism | hsa00564 | 5.18 | 0.42 | 6 |
| Glycerolipid metabolism | hsa00561 | 3.32 | 0.22 | 3 |
| Arachidonic acid metabolism | hsa00590 | 0.67 | 0.31 | 2 |
| Nicotinate and nicotinamide metabolism | hsa00760 | 0.66 | 0.19 | 1 |
| Biotin metabolism | hsa00780 | 0.96 | 0.15 | 1 |
Impact, impact value of metabolic pathway determined by topology analysis; Hits, the number of differential metabolites matching the pathway; PCa, prostate cancer; BPH, benign prostatic hyperplasia; PSA, prostate-specific antigen; KEGG, Kyoto Encyclopedia of Genes and Genomes.