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. 2021 Oct 15;9:728188. doi: 10.3389/fcell.2021.728188

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Copyright © 2021 Chen, Fan, Zhu, Guo, Ye, Dai, Guo, Hu, Miao and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VA injection stimulated HF regrowth by lowering dWAT inflammation. (A) VA injection stimulated HF regenerative behavior in aged mice. (B) The weight of the back skin hair in the old mice after VA treatment was significantly heavier than that before VA treatment, while no difference was found in young mice. n = 10. (C) Increased ki67 signaling was identified in the VA group. Scale bars = 100 μm. (D) Decreased levels of TNF-a, CCL2, IL-5, CSF2, and increased IL-10 were proved in dWAT after VA treatment. (E) Quantification of positive cells in each hair follicle about ki67, β-catenin, and FGF5. (F) Increased β-catenin signaling and reduced FGF5 level were identified in the VA group. Scale bars = 100 μm. n = 6. ns, Not Significant. ^∗∗P < 0.01, and ***P < 0.0001.