Table 2.

Comparisons of Serum metabolic biomarkers.

Number	Metabolites	Formula	Category	Mass(M/Z) 2	RT(Min) 1	LA+LPS VS LPS		LA+LPS VS ANT+LPS
						FC	P value	FC	P value
1	3,8-Dihydroxy-6-methoxy-7(11)-eremophilen-12,8-olide	C16H24O5	Lipids and lipid-like molecules	331.1299	3.5549	1.2581*	0.0436	1.2432	0.0663
2	PS(14:1(9Z)/18:0)	C38H72NO10P	Lipids and lipid-like molecules	756.4795	9.2650	1.3076**	0.0021	1.3434***	0.0000
3	Mactraxanthin	C40H60O6	Lipids and lipid-like molecules	678.4710	9.1518	1.2785**	0.0023	1.1194**	0.0023
4	12-Hydroxy-8,10-octadecadienoic acid	C18H32O3	Lipids and lipid-like molecules	295.2275	8.3016	1.2530*	0.0224	1.4020*	0.0164
5	3,4-Dimethyl-5-pentyl-2-furanpentadecanoic acid	C26H46O3	Lipids and lipid-like molecules	451.3427	9.1118	1.2052*	0.0427	1.3609*	0.0147
6	Lactosylceramide (d18:1/12:0)	C42H79NO13	Lipids and lipid-like molecules	788.5444	9.3136	0.9707	0.7236	0.7928*	0.0327
7	3-hydroxytetradecanoyl carnitine	C21H41NO5	Lipids and lipid-like molecules	370.2956	6.3694	0.9406	0.3435	0.7980*	0.0152
8	Quinquenoside F1	C42H74O15	Lipids and lipid-like molecules	836.5421	9.3136	1.0397	0.5084	0.8283*	0.0446
9	PS(18:3(9Z,12Z,15Z)/20:0)	C44H80NO10P	Lipids and lipid-like molecules	814.5597	9.4268	0.9547	0.5517	0.7819*	0.0301
10	PS(14:0/24:1(15Z))	C44H84NO10P	Lipids and lipid-like molecules	840.5743	9.6857	0.9879	0.7992	0.8057*	0.0263
11	PE-NMe2(16:0/18:4(6Z,9Z,12Z,15Z))	C41H74NO8P	Lipids and lipid-like molecules	772.5495	9.6372	0.9924	0.9230	0.8021*	0.0390
12	Monoisobutyl phthalic acid	C12H14O4	Benzenoids	205.0861	7.0005	1.5611***	0.0000	1.0311	0.0744
13	1-H-Inden-1-one,2,3-dihydro-3,3,5,6-tetramethyl	C13H16O	Benzenoids	233.0922	1.6437	1.2735*	0.0229	1.4919***	0.0000
14	2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylpropanamide	C14H17N3O5	Benzenoids	325.1509	1.0932	1.0824	0.3580	1.2394*	0.0339
15	2’’,4’’,6’’-Triacetylglycitin	C28H28O13	Phenylpropanoids and polyketides	614.1822	5.6900	0.7859**	0.0065	0.7612**	0.0028
16	Daidzein	C15H10O4	Phenylpropanoids and polyketides	255.0654	3.4566	1.2876*	0.0256	1.3217*	0.0146
17	Indole-3-carbinol	C9H9NO	Organoheterocyclic compounds	189.1021	1.5305	1.2283*	0.0328	0.9617	0.7315
18	Plantagonine	C10H11NO2	Organoheterocyclic compounds	178.0863	2.3075	1.1020	0.1699	1.2178**	0.0099
19	Spirolide B	C42H63NO7	Organoheterocyclic compounds	694.4662	8.9901	1.3447**	0.0034	1.1670	0.0009
20	Hydroxynalidixic acid	C12H12N2O4	Organoheterocyclic compounds	231.0765	1.1904	1.1852	0.1249	1.2832*	0.0313
21	Hydroxyphenylacetylglycine	C10H11NO4	Organic acids and derivatives	208.0608	1.5246	1.0658	0.1244	1.2213**	0.0022
22	Alanylclavam	C8H12N2O4	Others	201.0871	0.8988	1.1186	0.1095	1.2082*	0.0128
23	Nicotyrine	C10H10N2	Others	159.0917	2.3075	1.1694	0.1763	1.3194*	0.0288
24	2-Ethylacrylylcarnitine	C12H21NO4	Others	244.1545	3.2139	0.9204	0.3214	0.7578*	0.0175
25	(3-Arylcarbonyl)-alanine	C10H11NO3	Others	194.0813	1.4333	1.1501	0.0756	1.3030**	0.0031
26	PGPC	C29H56NO10P	Others	608.3567	8.1695	1.3652**	0.0066	1.2813***	0.0006
27	PAz-PC	C33H64NO10P	Others	666.4351	8.4563	1.2456**	0.0068	1.1313	0.0026

¹RT means retention time. ²FC is the fold change (differential multiple) of the metabolite expression between groups (LA vs. LA+LPS, LA+LPS vs. ANT+LPS). *P < 0.05, **P < 0.01, ***P < 0.001.