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. 2021 Oct 15;12:725129. doi: 10.3389/fimmu.2021.725129

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Copyright © 2021 Ndungo, Andronescu, Buchwald, Lemme-Dumit, Mawindo, Kapoor, Fairman, Laufer and Pasetti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shigella-specific maternal antibody repertoire and placental transfer efficiency. (A) IgG against Shigella LPS and protein antigens in maternal (M) and cord blood (CB) sera. Symbols represent individual titers. Asterisks indicate statistically significant differences determined by paired t-test; *P < 0.05, ****P < 0.0001. (B) Placental transfer ratios (cord blood titer/maternal titer) for antibodies against each antigen. Whiskers show minimum and maximum values. Line is at ratio = 1. (C) Associations between maternal and cord blood titers for each antigen. Pearson’s r and P values are shown within each graph.