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. 2021 Oct 15;12:725129. doi: 10.3389/fimmu.2021.725129

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Copyright © 2021 Ndungo, Andronescu, Buchwald, Lemme-Dumit, Mawindo, Kapoor, Fairman, Laufer and Pasetti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IgG subclass distribution of maternal and infant placentally-acquired antibodies. (A) Radar plots depict IgG1, IgG2, IgG3, and IgG4 levels against Shigella antigens measured in maternal and cord blood sera diluted at 1:100. Symbols represent the geometric mean Electro Chemiluminescence (ECL) Signal. (B) Heatmap representing median placental transfer ratios (cord blood titer/maternal titer) for Shigella antigen-specific IgG and IgG subclasses. Statistically significant differences between the transfer ratio of each IgG subclass compared to the total IgG transfer ratio were determined by one-way ANOVA with Dunnett’s post-test correction following ROUT analysis to exclude outliers; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.