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. 2021 Oct 15;12:725129. doi: 10.3389/fimmu.2021.725129

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Copyright © 2021 Ndungo, Andronescu, Buchwald, Lemme-Dumit, Mawindo, Kapoor, Fairman, Laufer and Pasetti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal and placentally-acquired infant functional antibodies against Shigella. (A) Serum bactericidal antibody (SBA) and (B) opsonophagocytic killing antibody (OPKA) titers measured in maternal (M) and cord blood (CB) sera (left graphs). Data represent individual titers. Placental transfer ratios (cord blood titer/maternal titer) for each dyad are shown on the right. Asterisks indicate statistically significant differences as determined by one-way ANOVA with a Tukey’s post-test correction; **P < 0.01, ***P < 0.001, ****P < 0.0001. Whiskers indicate minimum and maximum values. Line is at ratio = 1. (C, D) Associations between maternal (M) and cord blood (CB) SBA and OPKA titers, respectively. Pearson’s r and P values are shown within each graph.