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. 2021 Oct 15;12:725129. doi: 10.3389/fimmu.2021.725129

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Copyright © 2021 Ndungo, Andronescu, Buchwald, Lemme-Dumit, Mawindo, Kapoor, Fairman, Laufer and Pasetti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shigella LPS-specific antibodies are the main contributors of bactericidal activity. Percent killing of S. flexneri 2a in a representative maternal (A) and cord blood (B) serum pair depleted of antigen-specific antibodies. (C) Killing curves of either wild-type (WT) S. flexneri 2a 2457T (clear symbols) or S. flexneri 2a BS103 (virulence plasmid-cured strain, shaded symbols) by hyperimmune control serum (control) and a representative maternal or cord blood serum pair at different dilutions. (D) Bactericidal titers of serum against S. flexneri 2a WT (clear bars) or BS103 (shaded bars).