Table 2.

IC₅₀ values for the growth inhibition of hematologic malignant cells by PLX51107 and PLX2853.

Cell Line	Histologic Type	PLX51107		PLX2853
		IC50 (μM) a	CI95 (μM) b	IC50 (μM) a	CI95 (μM) b
DOHH2	Lymphoma, diffuse large B-cell	0.28	0.24-0.33	0.017	0.016, 0.018
HEL 92.1.7	Leukemia, acute erythroid	0.36	0.33, 0.39	0.042	0.034-0.054
Kasumi-1	Leukemia, acute myeloblastic	0.074	0.067-0.083	0.0043	0.0037-0.0051
MEC-1	Leukemia, chronic B cell	0.18	0.14-0.23	0.023	0.020, 0.026
MEC-2	Leukemia, chronic B cell	0.72	0.58-0.89	0.11	0.089, 0.13
MM.1S	Multiple myeloma	0.22	0.17-0.29	0.016	0.011-0.025
MUTZ-8	Leukemia, acute myeloid	1.4	1.3-1.6	0.11	0.11, 0.11
MV-4-11	Leukemia, acute myeloid	0.062	0.056-0.069	0.0041	0.0035-0.0048
NALM-6	Leukemia, acute lymphoblastic	0.14	0.14, 0.14	0.0096	0.0061-0.015
OCI-AML-2	Leukemia, acute myeloid	0.13	0.12-0.15	0.011	0.010, 0.011
OCI-AML-3	Leukemia, acute myeloid	0.071	0.068, 0.074	0.0049	0.004-0.0061
OCI-LY3	Lymphoma, diffuse large B-cell	0.4	0.36-0.46	0.026	0.017-0.041
P12-ICHIKAWA	Leukemia, precursor T-cell acute lymphoblastic	0.32	0.27-0.38	0.018	0.017, 0.020
RAMOS (RA1)	Lymphoma, Burkitt	0.64	0.56-0.73	0.037	0.036, 0.038
SET-2	Leukemia, acute megakaryoblastic	0.15	0.13-0.17	0.011	0.011, 0.012
YNH-1	Leukemia, acute myeloid	0.14	0.12-0.15	0.011	0.010,0.012

^aGeometric mean of the IC₅₀.

^b95% Confidence interval for geometric mean if n ≥ 3 or individual IC₅₀ if n<3.