TABLE 2.

Significant metabolic pathways involved in the six cardiovascular diseases.

Traits	Metabolites pathway	Involved metabolites	p Value	Database
AF	Aminoacyl-tRNA biosynthesis	Glycine, l-Alanine, l-Lysine	0.0029	KEGG
AF	Carnitine Synthesis	Glycine, l-Lysine	0.0192	SMPDB
CAD	Caffeine metabolism	1-Methylxanthine, Caffeine	0.0024	KEGG
CAD	Carnitine Synthesis	Glycine, l-Carnitine	0.0192	SMPDB
CAD	Bile Acid Biosynthesis	Glycine, Taurodeoxycholic acid, Deoxycholic acid	0.0436	SMPDB
DBP	Primary bile acid biosynthesis	Glycine, Glycocholate	0.0272	KEGG
PP	Phenylalanine metabolism	Hippurate	0.0382	KEGG
SBP	Caffeine Metabolism	Caffeine, 1,3,7-Trimethyluric acid	0.0334	SMPDB
HF	Aminoacyl-tRNA biosynthesis	l-Cysteine, Glycine, l-Isoleucine	0.0039	KEGG
HF	Glutathione metabolism	Glycine, l-Cysteine	0.0157	KEGG
HF	Glycine, serine and threonine metabolism	Glycine, l-Cysteine	0.0214	KEGG
HF	Primary bile acid biosynthesis	Glycine, Cholic acid	0.0400	KEGG
HF	Thiamine metabolism	l-Cysteine	0.0487	KEGG
HF	Bile Acid Biosynthesis	Glycine, Cholic acid, Deoxycholic acid glycine conjugate	0.0436	SMPDB
MI	Caffeine metabolism	Caffeine	0.0444	KEGG

Note: AF, atrial fibrillation; DBP, diastolic blood pressure; SBP, systolic blood pressure; PP, pulse pressure; MI, myocardial infarction; CAD, coronary artery disease; AIS, any ischemic stroke; HF, heart failure; KEGG, Kyoto encyclopedia of genes and genomes; SMPDB, small molecule pathway database.