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. 2021 Oct 15;15:717008. doi: 10.3389/fnbeh.2021.717008

FIGURE 1.

FIGURE 1

Effects of puerarin (Pur) on occlusion of bilateral common carotid arteries (BCCAO)-induced spatial memory impairment. (A) Timeline of surgery (BCCAO), drug administration and behavioral assays. (B) Results of the Morris water maze (MWM) (days 28 following BCCAO) in the sham and BACCO groups. (C) Escape latency (starting site to the hidden platform) at days 24–28 post-BCCAO). (D) Escape latency at days 59–63, during Pur treatment. (E) Numbers of crossings in the target quadrant within 60 s in the probe trial on day 63. (F) Percentages of time spent in the target quadrant within 60 s in the probe trial (no platform) on day 63. (G) Swimming speed (path length by escape latency) in each group at days 59–63. Values were mean ± SEM (n = 6). *P < 0.05, **P < 0.01 vs. Sham; #P < 0.05, ##P < 0.01 vs. BCCAO; $$P < 0.01 vs. BCCAO + Pur (150 mg/kg/day).