Effect of atrial stretch and ICA on action potential durations. (A,B) Effects of intervention on atrial APD90 (A,B), n = 11; and ventricular APD90 recorded at pacing basic cycle length of 200 ms (C,D) n = 9 and 10. Data are presented as mean ± SEM. Vehicle control group at top (black) and treatment group (ICA 1 µM) at bottom (red). Multiple comparisons tests were performed. For simplicity only the comparisons: baseline to 30 min; 0 mmHg to 20 mmHg; 20 mmHg to 0 mmHg are shown. mmHg refers to LA balloon pressure. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)