Table 2.

Anticonvulsant and anti-seizure activity of C. sativum and linalool

Extract/ Component	Type of study	Doses	Results	Ref.
The seeds aqueous extract	Induced seizure in mice	0.5 g/kg, i.p.	Tonic seizures duration was decreased, clonic convulsion onsets were postponed.	(Hosseinzadeh and Madanifard, 2000 ▶)
The seeds ethanolic extract		3.5 and 5 g/kg, i.p.	Tonic seizures duration was decreased, clonic convulsion onsets were postponed.	(Hosseinzadeh and Madanifard, 2000 ▶)
Aqueous and ethanolic extracts and essential oil		200, 400, 600 and 800 mg/kg, i.p.	Myoclonic and clonic seizures onsets were postponed.	(Emamghoreishi and Heidari-Hamedani, 2010 ▶)
The seeds hydroalcoholic extract and essential oil		5 mg/kg, i.p.	Myoclonic and clonic seizures onsets were postponed.	(Emam and Heydari, 2008 ▶)
The leaves hydroalcoholic extract	PTZ- induced seizure in rat	100, 500 and 1000 mg/kg, i.p.	MCS and GTCS latencies were increased Cortical tissues total thiol contents were improved.	(Karami et al., 2015 ▶)
Aerial parts fractions		25 and 100 mg/kg, i.p.	GTCS latency was significantly improved Hippocampal MDA concentrations were decreased cortical and hippocampal tissues thiol contents were improved.	(Anaeigoudari et al., 2016 ▶)
Linalool	In vitro	0.3 mM or 1.0 mM	Modulated glutamate activation expression in the rat cortex membrane cells.	(da-Silva et al., 1990 ▶)
Linalool	Quinolinic acid induced seizure in rat	350 mg/kg, i.p.	Linalool delayed of NMDA (270mg/kg, i.p.) induced seizures onsets which was comparable to the effects of diazepam.	(da-Silva et al. 1990 ▶)
Linalool	Quinolinic acid induced seizure in mic	1.0 or 3.0 mM	Reduced potassium-stimulated glutamate release as well as glutamate uptake (90%)	(Brum et al., 2001 ▶)