Table 3.

Effect of P. eldarica bark hydroalcoholic extract and leaves essential oil in croton test in mice (n=6)

Treatment	Dose	Mean of ear edema (mg)	% inhibition
Control	-	15.78	-
Hydroalcoholic ext.	100 mg/kg	8.85	43.9*
	200 mg/kg	8.15	48.4*
	400 mg/kg	7.62	51.7*
Essential oil	50 µl/kg	13.33	15.5
	100 µl/kg	11.07	30.0*
	200 µl/kg	11.08	29.8*
Indomethacin	10 mg/kg	2.7	82.9***

Vehicle, different doses of the hydroalcoholic extract or the essential oil or indomethacin were administered (i.p.) 30 min prior to topical application of croton oil (5% in acetone, 20 µl) on the right ear. Six hours later, the animals were sacrificed and 6-mm disks were taken from both ears and weighed. The weight difference was an index of edema. % inhibition= [(mean of ear edema in control group- mean of ear edema in test group)]/ mean of ear edema in the control group X 100. *p<0.05 and ***p<0.001 in comparison with the control group.