Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 15;12:775128. doi: 10.3389/fimmu.2021.775128

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Marchand and Pinho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Therapeutic targeting of the leukemic niche. The different molecular interactions between LSCs and the bone marrow niche constituents are shown. Inhibitors are labeled in red. Most of the drugs shown in the figure are under pre-clinical or early clinical development. IL-1, interleukine-1; Ab, antibody; CD, cluster of differentiation, FA, fatty acid; LSC, leukemic stem cell; MSC, mesenchymal stem cell; NOX2, NADPH oxidase 2; NO, nitric oxide; ECM, extracellular matrix; VEGF, vascular endothelial growth factor; HAP, Hypoxia-activated prodrugs; PPARγ, Peroxisome Proliferator-activated Receptor gamma; VCAM-1, Vascular Cell Adhesion Molecule-1; BETPs, Bromodomain Extra-Terminal Protein.