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. 2021 Oct 15;12:746879. doi: 10.3389/fgene.2021.746879

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Copyright © 2021 Qi, Gao, Cai, Han, Qi, Ni, Sun, Huang, Chen, Wu and Kapranov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between the blood aging-related genes from this study and aging-associated transcriptome signatures from other studies. (A) Overlap between the blood aging-related genes from this study and genes differentially expressed with chronological age in peripheral blood transcriptome from Peters et al. (2015). Note, four genes from the study of Peters et al. were excluded since their Entrez records were discontinued or cannot be mapped to any records in the Ensembl database. (B) Overlap between the blood aging-related genes and cellular senescence signature genes from Chatsirisupachai et al. (2019). Note, gene with Entrez ID 10631 was included in both the up- and downregulated senescence signature gene sets in the study from Chatsirisupachai et al., and we kept it as it was in our analysis. (C,D) Overlap between the blood aging-related genes and aging-associated tissue-specific transcriptomic changes from Chatsirisupachai et al. (2019). (A,B) The p-values of Fisher’s exact tests are shown in cells of the heatmaps; the numbers in the Venn diagrams represent numbers of genes. (C,D) The numbers of overlapping genes and the p-values of Fisher’s exact tests (in the parentheses) are shown in the cells; the numbers in the x and y axes are the numbers of genes. (A–D) N.S. denotes nonsignificant overlap; color scale represents the log2 odds ratios. The dagger sign “†” marks the blood aging-related genes from this study.