Table 1.
LncRNAs in disease or normal cells and related m6A effectors.
| LncRNA | Cancer | Expression | Pathway | m6A effector | Reference |
|---|---|---|---|---|---|
| RP11 | CRC | Upregulation | ZEB1 | hnRNPA2B1 METTL3 ALKBH5 |
(19) |
| GAS5 | CRC | Downregulation | YAP | YTHDF3 | (28) |
| NEAT1 | GC | Upregulation | EZH2 | ALKBH5 | (29) |
| PVT1 | OS | Upregulation | — | ALKBH5 YTHDF2 |
(30) |
| XIST | human cells | — | — | METTL3, YTHDC1 RBM15/15B/WTAP |
(4) |
| MALAT1 | mESC | — | — | METTL16 | (7) |
| DANCER | PC | — | — | IGF2BP2 | (31) |
| FAM225A | NPC | Upregulation | ITGB3/FAK/PI3K/AKT | METTL3 | (32) |
| Linc1281 | mESC | — | Lin28 | METTL3 | (33) |
| Linc00958 | HCC | Upregulation | SREBP1/FASN/SCD1/ACC1/HDGF | METTL3 | (34) |
| MEG3 | HCC | Downregulation | BTG2 | METTL3 | (35) |
| PCAT6 | PCa | Upregulation | IGF1R | METTL3 | (36) |
| XIST | OPLL | Upregulation | USP8 | METTL3 | (37) |
| Linc00470 | GC | Upregulation | PTEN | METTL3 YTHDF2 |
(38) |
| BLACAT2 | GC | Upregulation | — | METTL3 | (39) |
| Olfr29-ps1 | MDSCs | Upregulation | IL-6/MyD88 | METTL3 | (40) |
| LINC00958 | BC | Upregulation | YY1 | METTL3 | (41) |
| GAS5-AS1 | CC | Downregulation | — | YTHDF2, ALKBH5 |
(42) |
| FOXM1-AS | GBM | Upregulation | SOX2 | ALKBH5 | (43) |
| KCNK15-AS1 | PC | Downregulation | — | ALKBH5 | (44) |
| ABHD11-AS1 | NSCLC | Upregulation | — | METTL3 | (45) |
| ARHGAP5-AS1 | GC | Upregulation | SQSTM1 | METTL3 | (46) |
| HOTAIR | NSCLC | — | — | m6A signal | (47) |
CRC, colorectal cancer; GC, gastric cancer; OS, osteosarcoma; mESC, mouse embryonic stem cells; PC, pancreatic cancer; NPC, nasopharyngeal carcinoma; HCC, hepatocellular carcinoma; PCa, prostate cancer; OPLL, ossification of the posterior longitudinal ligament; GC, gastric cancer; MDSCs, myeloid-derived suppressor cells; BC, breast cancer; CC, cervical cancer; GBM, glioblastoma; PC, pancreatic cancer; NSCLC, non-small cell lung cancer.