Table 2.
MicroRNAs in disease and related m6A effectors.
| MiRNA | Disease | Expression | Pathway | m6A Effector | Reference |
|---|---|---|---|---|---|
| miR221/222 | BCA | Upregulation | PETN | METTL3 | (60) |
| miR-1246 | CRC | Upregulation | SPRED2, Raf/MEK/ERK | METTL3 | (64) |
| miR-1246 | NSCLC | Upregulation | PEG3 | METTL3 | (65) |
| miR-221-3p | BC | Upregulation | HIPK2/Che-1 | METTL3 | (67) |
| miR-143-3p | NSCLC | Upregulation | VASH1/VEGFA | METTL3 | (68) |
| miR-21-5p | ORF | Upregulation | SPRY1/ERK/NF-kB | METTL3 | (66) |
| miR-873-5p | mRTECs | — | Keap1/Nrf2 | METTL3 | (69) |
| miR126 | HCC | Downregulation | — | METTL14 | (71) |
| miRNA-375 | CRC | Downregulation | YAP/SP1 | METTL14 | (72) |
| miR-25-3p | PC | Upregulation | PHLPP2/AKT-p70S6K | METTL3 NKAP |
(16) |
| miR-145 | HCC | Downregulation | — | YTHDF2 | (73) |
| miR-4729 | Hemorrhoids | Downregulation | TIE1/VEGFA | METTL14 | (74) |
| miR-103-3p | Osteoporosis | Upregulation | — | METTL14 | (75) |
| miR-186 | HB | Downregulation | Wnt/β-catenin | METTL3, YTHDF2 | (76) |
| miR-338-5p | GC | Downregulation | EED/CDCP1 | METTL3 | (77) |
| miR-4443 | NSCLC | Upregulation | FSP1 | METTL3 | (78) |
| miR-24-2/ miR6079 |
HCC | Upregulation | Pim1/JMJD2A | METTL3 | (70) |
| miR-33a | NSCLC | Downregulation | EGFR | METTL3 | (79) |
| miR-600 | NSCLC | Downregulation | EGFR/PI3K/AKT β-catenin |
METTL3 | (80) |
| miR-29a | GBM | Downregulation | QKI-6/EGFR ERK/PI3K/AKT | WTAP | (81) |
| miR-let-7g | BC | Downregulation | HBXIP | METTL3 | (82) |
BCA, bladder cancer; mRTECs, mouse renal tubular epithelial cells; HB, hepatoblastoma; BC, breast cancer. ORF, obstructive renal fibrosis.