Table 1.
MiR-149-5p in different human cancers.
| Human System | Tumor type | Upstream regulator | Target gene | Mechanism | Role | References |
|---|---|---|---|---|---|---|
| Reproductive | Breast cancer | NA | MyD88 | Reverse PTX resistance | Tumor suppressor | (36) |
| NA | IL-6 | Reverse Trastuzumab resistance | (38) | |||
| Circ_0072995 | SHMT2 | Suppress cell malignant properties and anaerobic glycolysis | (39) | |||
| NA | CCT3 | Unbalancing the homeostasis in intracellular ROS and the profile of free amino acids in energy metabolism to spur apoptosis | (14) | |||
| Ovarian cancer | NA | MST1 and SAV1 | Enhance Cisplatin resistance | Controversy | (41) | |
| Circ_CELSR1 | SIK2 | Reverse PTX resistance | (43) | |||
| PVT1 | FOXM1 | Suppress ovarian cancer cell viability and migration | (44) | |||
| Cervical cancer | Hsa_circ_0075341 | AURKA | Weaken the proliferation and invasion of cervical cancer cells | Tumor suppressor | (23) | |
| Endometrial carcinoma | Hsa_circ_0061140 | STAT3 | Suppress tumorigenesis | Tumor suppressor | (46) | |
| Prostate carcinoma | NA | RGS17 | Weaken the malignant degree of PCa cells | Tumor suppressor | (48) | |
| NA | CCT3 | Unbalancing the homeostasis in intracellular ROS and the profile of free amino acids in energy metabolism to spur apoptosis | (14) | |||
| Digestive | GC | CircNRIP1 | AKT1 | Inhibit the progression of GC | Tumor suppressor | (13) |
| BLACAT1 | KIF2A | Inhibit the proliferation, migration and invasion of GC cells | (50) | |||
| CircNHSL1 | YWHAZ | Inhibit the progression of GC | (51) | |||
| Circ_0044516 | HuR | Inhibit the progression of GC | (52) | |||
| HCC | LINC00461 | LRIG2 | Inhibit the progression of HCC | Tumor suppressor | (56) | |
| PART1 | MAP2K1 | Inhibit proliferation, migration and invasion of HCC cells | (57) | |||
| NEAT1 | AKT1 | Reverse Sorafenib resistance | (59) | |||
| NA | MMP9 | Inhibit the progression of HCC | (15) | |||
| CRC | LINC00460 | CUL4A | Inhibit cell proliferation and promote apoptosis | Tumor suppressor | (16) | |
| LINC00460 | BGN | Prevent the metastasis of CRC cells | (22) | |||
| LINC00460 | Mutant p53 | Reverse Oxaliplatin resistance | (21) | |||
| DLGAP1-AS1 | TGFB2 | Improve the sensitivity of 5-FU | (67) | |||
| Circ5615 | TNKS | Inhibit the proliferation of CRC cells | (68) | |||
| CircCTNNA1 | FOXM1 | Inhibit CRC progression | (69) | |||
| Oral cancer | NA | TGF β2 | Enhance the chemosensitivity of OSCC cells to cisplatin | Tumor suppressor | (75) | |
| CircBICD2 | IGF2BP1 | Inhibit OSCC progression | (70) | |||
| DLEU1 | CDK6 | Inhibit the tumorigenesis of OSCC | (76) | |||
| Esophageal cancer | DRAIC | NFIB | Inhibit the proliferation and invasion as well as promote apoptosis and autophagy of esophageal cancer cells. | Tumor suppressor | (72) | |
| CIRC_0000654 | IL-6 | Inhibit the progression of esophageal cancer | (73) | |||
| Respiratory | Lung cancer | PCAT-1 | LRIG2 | Inhibit the development of NSCLC | Controversy | (81) |
| HNF1A-AS1 | CDK6 | Inhibit NSCLC progression | (82) | |||
| MIAT | FOXM1 | Inhibit NSCLC progression | (83) | |||
| HOTAIR | HNRNPA1 | Inhibit the Cell Growth, Migration and Invasion in NSCLC | (84) | |||
| CircFOXM1 | ATG5 | Suppress NSCLC development | (85) | |||
| NA | B3GNT3 | Antagonize the tumorigenicity | (86) | |||
| HOTAIR | DCLK1 | Reverse Cisplatin resistance | (89) | |||
| LINC00460 | IL-6 | Reverse EGFR-TKI resistance | (91) | |||
| NA | AMOTL2 | Promoted the growth and inhibited the apoptosis of tumor cells | (17) | |||
| NPC | LINC00460 | IL6 | Inhibit the proliferation of NPC cells | Tumor suppressor | (94) | |
| Urinary | RCC | NA | FOXM1 | Inhibit the proliferation, migration and invasion of renal cancer cells. | Tumor suppressor | (98) |
| BC | CircRNA_100146 | RNF2 | Inhibit the proliferation, migration and invasion of BC cells | Tumor suppressor | (102) | |
| Endocrine | TC | Circ-FLNA | MMP9 | Inhibit the invasion and migration of PTC cells | Tumor suppressor | (106) |
| NA | GIT1 | Inhibit the proliferation and invasion of MTC cells | (108) | |||
| Circulatory | Leukemia | NA | FASLG | Inhibit apoptosis of AML cell | Oncogene | (19) |
| CircADD2 | AKT2 | Promote proliferation and inhibit apoptosis | (18) | |||
| Nervous | Glioma | NA | CDK6 | Inhibit the proliferation of glioma cells and enhance the killing effect of temozolomide on glioma cells | Tumor suppressor | (113) |
| Motor | Osteosarcoma | NA | TNFRSF12A | Suppress osteosarcoma cell growth | Tumor suppressor | (115) |
NA, not available.