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. 2021 Oct 15;12(10):1622–1654. doi: 10.4239/wjd.v12.i10.1622

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Functional structure of estrogen receptors α and estrogen receptors β. Dominion names (A to F), and common denominations for the main functions are included: N-terminus dominion; DNA binding dominion, activation function site 1 of the estrogen receptors and activation function site 2 of the estrogen receptors. The graph is not drawn to scale and represents the complete (highest molecular weight) form for each of the two families of nuclear ERs. NTD: N-terminus dominion; DBD: DNA binding dominion; AF1: Activation function site 1 of the estrogen receptors; AF2: Activation function site 2 of the estrogen receptors.