Table 2.

Pancreatic ductal adenocarcinoma trials involving agents that target tumor metabolism

Drug	Target	Trial description	NCI trial number
IACS-010759	OXPHOS inhibitor	Phase I, in advanced cancers	NCT03291938
CPI-613	PDH/alpha KDH inhibitor	Phase I, combination with Gem + nab-paclitaxel	NCT03435289
CPI-613	PDH/alpha KDH inhibitor	Phase II, combination with FOLFIRINOX	NCT03699319
CPI-613	PDH/alpha KDH inhibitor	Phase III, combination with modified FOLFIRINOX	NCT03504423
Metformin and atorvastatin	Metabolic inhibitors	Metformin + Atorvastatin + Doxycycline + Mebendazole in cancers	NCT02201381
L-glutamine	Glutamine analog	Phase I, combination with Gem + nab-paclitaxel	NCT04634539

OXPHOS: Oxidative phosphorylation; PDH: Pyruvate dehydrogenase; KDH: Ketoglutarate dehydrogenase.