Table 1.
Incidence of various tumors induced in different treatment groups
|
Group
|
Total number of tumors
|
Adenoma incidence, %
|
Adenocarcinoma incidence, %
|
With lymphytic metastasis (%)
|
|||||
|
Mild
|
Moderate
|
Severe
|
Well-differentiated
|
Moderate-differentiated
|
Poor-differentiated
|
Mucinous
|
Metastasis rate
|
||
| Control | - | - | - | - | - | - | - | - | - |
| DMH | 23 | 2/23 (8.7) | 2/23 (8.7) | 3/23 (13) | 12/23 (52.2) | 4/23 (17.4) | 3/23 (13.0) | - | - |
| Cold exposure | 38 | 1/38 (2.6) | 2/38 (5.3) | 3/38 (7.8) | 5/38 (15.8)b | 8/38 (21.1) | 15/38 (36.8)a | 4/38 (10.5) | 20.0 |
| Capsaicin | 34 | 2/31 (5.9) | 1/34 (2.9) | 4/31 (12.9) | 7/31(22.6)a | 12/31 (38.7) | 7/31(22.6) | 1/31 (3.2) | - |
Values are expressed as the proportion of lesions-bearing rats. n = 10 rats/group. Incidence data was analyzed by using chi-square or Fisher’s exact test.
a
P < 0.05.
b
P < 0.01.
1,2-dimethylhyrazine compared with cold exposure and capsaicin-treated group. DMH: 1,2-Dimethylhyrazine.