Table 2.

Landmark trails on use of neoadjuvant chemotherapy

Study	No. of patients	Treatment arms	Resection rate, %	R0	Median DFS in mo	Median OS in mo
PACT-15[44]	93 Resectable	Surgery + gemcitabine	85	27	4.7	20.4
		Surgery + 6 PEXG	90	37	12.4	26.4
		3PEXG + surgery + 3 PEXG	84	63	16.9	16.9
PREOPANC-01[48]	248 Resectable + BRPC	26Gy/15fr + gemcitabine	60	63	9.9	17.1
		Surgery	72	31	7.9	13.7

BRPC: Borderline resectable pancreatic cancer; DFS: Disease-free survival; OS: Overall survival; PEXG: Cisplatin, epirubicin, gemcitabine, and capecitabine.