FIGURE 1.

Cognitive performance of SAMR1 (n = 5), SAMP8 (n = 5), and SAMP8 treated with donepezil (n = 4), during the training and probe trial session of the Morris water maze test. (A) Escape latency in SAMR1, SAMP8 and SAMP8 treated with donepezil mice, during seven consecutive days of Morris water maze test training; (B) number of target crossings and (C) entries into the target quadrant. Data are expressed as mean ± SEM obtained from six animals. Differences among groups were evaluated by two‐way analysis of variance followed by post hoc analysis with the Fisher LSD test or a one‐way ANOVA followed by Tukey's post hoc test where appropriate. *p < .05, significant differences versus age‐matched SAMR1; ^£ p < .05, significant differences versus age‐matched SAMP8