FIGURE 2.

Vascular results. (A) Endothelial‐dependent relaxations of mesenteric resistance arteries to acetylcholine alone, or in combination with ascorbic acid or L‐NAME in SAMR1 (n = 5), SAMP8 (n = 5), and SAMP8 chronically treated with donepezil (n = 4) mice. Data are expressed as mean ± SD. Differences among groups were evaluated by one‐way ANOVA followed by Tukey's post hoc test **p < .001. (B) Effects on endothelial function of acute incubation with donepezil with or without ascorbic acid in vessels from SAMR1 (n = 3) or SAMP8 untreated (n = 3) mice. Data are expressed as mean ± SD. Differences among groups were evaluated by one‐way ANOVA followed by Tukey's post hoc test *p < .05. (C) Differences of Median‐Lumen (M/L) ratio and Media Cross Sectional Area (MCSA) between SAMR1 (n = 5), SAMP8 (n = 5) and SAMP8 supplemented with donepezil (n = 4) mice. Data are expressed as mean ± SD. Differences among groups were evaluated by one‐way ANOVA followed by Tukey's post hoc test. *p < .001 versus SAMR1; **p < .001 versus SAMP8