Table 2.
Summary of cases of Bacillus cereus reported in Pediatric Oncology patients.
| S. no | Author (ref no.) | Year | Diagnosis | Stage of Rx | Age | Sex | Symptoms on presentation | GI symptom | CNS symptom | CNS lesions | Other features | ANC | CVC | Steroid | IT chemo | Source | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Feldman et al.[13] | 1974 | ALL refractory/ relapse | NA | 17 | M | Fever, chest pain | NA | No | NA | Pneumonia, pulmonary infarct | 36 | NA | Yes | Yes | NA | Death |
| 2 | Guiot et al.[14] | 1986 | ALL | Induction | 18 | M | Wound on forearm | NA | Yes | CT- damaged BBB | Fever, drowsiness | 20 | NA | NA | NA | Wound | Death |
| 3 | Henrickson et al.[15] | 1989 | ALL | Remission | 5 | M | Swelling, redness in left 4th finger | No | No | NA | Cellulitis | Low | NA | NA | NA | NA | Recovery |
| 4 | Henrickson et a[15] | 1989 | Neuroblastoma | NA | 2 | M | URI,fever, swelling and vesicles in left hand | No | No | NA | No | Low | NA | NA | NA | NA | Recovery |
| 5 | Henrickson et al.[15] | 1989 | ALL | Induction | 8 | M | Eschar like lesion on toe, fever | No | No | NA | No | Low | NA | NA | NA | NA | Recovery |
| 6 | Jenson et al.[16] | 1989 | ALL | Induction | 3 | M | Fever, lethary, obtundation | No | Yes | Multiple brain abscesses | No | 20 | NA | Yes | Yes | NA | Recovery |
| 7 | Yoshida et al.[5] | 1993 | AML (M5b) | Induction | 15 | M | Fever, headache, vomiting, diarhoea | Yes | Yes | Subarachanoid hemorrhage | NA | NA | NA | NA | NA | NA | Death |
| 8 | Musa et al.[8] | 1999 | ALL | Induction | 14 | M | Fever, seizure | No | Yes | Brain herniation | Coma, liver enzymes derrangement | 100 | Yes | Yes | NA | NA | Death |
| 9 | Arnaout et al.[9] | 1999 | ALL relapse | Induction | 10 | F | Abdominal pain, lethargy | No | Yes | Multiple brain infarcts | Intravascular hemolysis | 0 | Yes | Yes | Yes | CVC | Recovery |
| 10 | Christenson et al.[17] | 1999 | ALL relapse | Induction | 10 | F | Abdominal pain, headache, diarrhea | Yes | No | NA | Shock | Low | Yes | NA | NA | CVC | Recovery |
| 11 | Christenson et al.[17] | 1999 | Acute leukemia | Induction | 5 | F | Abdominal pain, seizures | Yes | No | NA | Shock | Low | Yes | NA | NA | NA | Death |
| 12 | Christenson et al.[17] | 1999 | AML relapse | post BMT day 311 | 6 | M | Fever, abdominal pain, diarrhea | Yes | No | NA | No | NA | Yes | NA | NA | NA | Recovery |
| 13 | Gaur et al.[11] | 2001 | Nasopharyngeal carcinoma | NA | 16 | F | NA | No | No | NA | NA | NA | Yes | No | No | NA | Recovery |
| 14 | Gaur et al.[11] | 2001 | ALL | NA | 4 | M | NA | Yes | No | NA | NA | NA | Yes | Yes | No | NA | Recovery |
| 15 | Gaur et al.[11] | 2001 | NHL | NA | 17 | M | NA | No | No | NA | NA | NA | Yes | No | No | NA | Recovery |
| 16 | Gaur et al.[11] | 2001 | MDS | NA | 7 | M | NA | No | No | NA | NA | NA | Yes | No | No | NA | Recovery |
| 17 | Gaur et al.[11] | 2001 | Yolk sac tumor | NA | 5 | M | NA | Yes | No | NA | NA | NA | Yes | No | No | NA | Recovery |
| Seizure, altered | Diffuse cerebral edema, acute | ||||||||||||||||
| 18 | Gaur et al.[11] | 2001 | ALL | NA | 13 | F | sensorium | Yes | Yes | hydrocephalus | NA | 0 | Yes | Yes | Yes | NA | Recovery |
| 19 | Gaur et al.[11] | 2001 | Histiocytosis | NA | 10 | M | NA | Yes | No | NA | NA | NA | Yes | No | No | CVC | Recovery |
| 20 | Gaur et al.[11] | 2001 | ALL relapse | NA | 15 | F | Altered sensorium | Yes | Yes | Multiple brain infarcts, hydrocephalus | NA | 0 | Yes | Yes | Yes | NA | Death |
| 21 | Leonard et al.[18] | 2002 | Alveolar RMS | NA | 11 | M | Fever, seizures | No | Yes | Brain abscesses | Coinfection with Aspergillus like molds | Low | Yes | NA | NA | NA | Recovery |
| 22 | Saleeby et al.[19] | 2004 | ALL | Induction | 17 | F | NA | NA | NA | NA | NA | Low | NA | NA | NA | Tea bag | Recovery |
| 23 | Nishikawa et al.[20] | 2009 | ALL | Induction | 16 | F | Fever, disorientation | No | Yes | Brain abscess | Critical illness polyneuropathy | Low | Yes | Yes | Yes | NA | Recovery |
| 24 | Uchino et al.[12] | 2012 | AML | HiDAC | 18 | F | Seizures | No | No | NA | Central diabetes insipidus, DIC, grade 3 elevation of liver enzymes | 3 | Yes | NA | NA | NA | Recovery |
| 25 | Sharma et al.[21] | 2013 | ALL | maintenanc e | 5 | F | Fever, vomiting | Yes | No | NA | Endocarditis | NA | Yes | NA | NA | CVC | Recovery |
| Fever, headache, | Multiple brain | Ascending cholangitis, left homonymous | |||||||||||||||
| 26 | Hansford et al.[22] | 2014 | ALL | Induction | 8 | M | pain abdomen | Yes | Yes | abscesses | hemianopia | 30 | Yes | Yes | Yes | CVC | Recovery |
| 27 | Dabscheck et al.[23] | 2015 | ALL | Induction | 5 | M | Fever | No | Yes | Brain abscess | No | Low | NA | NA | NA | NA | Recovery |
| Fever, vomiting, | Acute renal failure, acute pulmonary | ||||||||||||||||
| 28 | Chou et al.[24] | 2016 | ALL | Induction | 15 | F | drowsiness | Yes | Yes | No | edema | Low | NA | Yes | Yes | NA | Death |
| 29 | Nath et al.[6] | 2017 | ALL | NA | 3 | M | NA | NA | NA | NA | Fulminant sepsis | 500 | NA | NA | No | NA | Death |
| 30 | Nath et al.[6] | 2017 | ALL | NA | 11 | F | NA | NA | NA | NA | NA | 400 | NA | NA | No | NA | Recovery |
| 31 | Nath et al.[6] | 2017 | ALL | NA | 3 | F | NA | NA | NA | NA | NA | 300 | NA | NA | No | NA | Recovery |
| 32 | Nath et al.[6] | 2017 | AML | NA | 14 | M | NA | NA | NA | NA | NA | 400 | NA | NA | No | NA | Recovery |
| 33 | Nath et al.[6] | 2017 | ALL | NA | 15 | M | NA | NA | NA | NA | Meningitis | 1900 | NA | NA | No | NA | Recovery |
| 34 | Nath et al.[6] | 2017 | Burkitt's lymphoma | NA | 4 | M | NA | NA | NA | NA | Cellulitis | 800 | NA | NA | No | NA | Recovery |
| 35 | Nath et al.[6] | 2017 | ALL | NA | 8 | F | NA | NA | NA | NA | Cellulitis | 1700 | NA | NA | No | NA | Recovery |
| 36 | Present case | 2022 | ALL relapse | Induction | 15 | M | Hematemesis, drowsiness | Yes | Yes | No | DIC, multiorgan dysfunction | 395 | Yes | Yes | Yes | NA | Death |