Table 4.

Reported clinical features of multisystem inflammatory syndrome in children

Affected organ system	Symptoms	Frequency of involvement (%)	Refs
Cardiovascular	Shock	40–80	210,234–236
	Cardiac arrhythmias	2	235
	Abnormal ST- or T-wave segment	22	235
	Prolonged QT interval	2	235
	Pericardial effusion	13–28	235,246
	Decreased LVEF by echo	31–58	234,235
	Increased troponin	68–95	234,235
	Myocarditis	36–87	210,236,246
	Coronary artery dilation on CT	27	235
	Coronary artery aneurysm Mild Moderate Giant	14–48 22 7 1	234–236 235 235 235
Gastrointestinal	Gastrointestinal symptoms	60–100	234–236
	Diarrhoea	38–72	210,235
	Vomiting	51–68	210,246
	Abdominal pain	19–71	210,235
	Ascites	21	235
	Ileitis	9	235
	Colitis	4	235
Ophthalmological	Conjunctivitis	32–83	234–236,246,264
	Periorbital erythema and oedema	20	264
Nervous system	Neurological symptoms	13–35	210,235,236,249
	Severe symptoms, including encephalopathy, stroke, central nervous system infection/demyelination, Guillain–Barré syndrome and acute cerebral oedema	3	249
Integumentary	Rash	50–70	234,236,246
	Erythematous skin rash	62	235
	Hyperaemia, oedema or desquamation of extremities	26–51	235,264
	Malar erythema	17	264
	Skin eruptions	9–14	264
	Desquamation in groin	26	236
Respiratory	Upper respiratory tract infection	34	235
	Lower respiratory tract infection	22	235
	Pleural effusion on CT	20	235
	Lung involvement on CT (bilateral pulmonary consolidation and ground-glass opacity)	13	235
Mucosal	Oral mucosa hyperaemia	41	235
	Red and/or cracked lips	37–49	246,264
	Strawberry tongue	11–23	246,264
	Lips and oral-cavity changes	74	234,236
Other	Lymphadenopathy (cervical)	19–61	235,236,246
	Extremity changes	8–52	234,236,246

LVEF, left ventricular ejection fraction.