Table 1.

Showing the details of ClinVar pathogenic mutations in BRCA1 and BRCA2 genes in 141 patients with ovarian cancer.

Patient ID	Tissue type	Gene	Exon	Mutated site	Protein	Variant types
1	Tumor tissue	BRCA1	10	c.3286C>T	p.Gln1096Ter	Nonsense
2	Tumor tissue	BRCA1	10	c.784C>T	p.Gln262Ter	Nonsense
3	Tumor tissue	BRCA1	10	c.3214delC	p.Leu1072Ter	Nonsense
4	Peripheral blood	BRCA1	10	c.2110_2111del	p.Asn704Cysfs∗7	Frameshift
5	Tumor tissue	BRCA1	10	c.2110_2111del	p.Asn704Cysfs∗7	Frameshift
6	Peripheral blood	BRCA1	10	c.4065_4068del	p.N1355Kfs∗10	Frameshift
7	Tumor tissue	BRCA1	10	c.4065_4068del	p.N1355Kfs∗10	Frameshift
8	Tumor tissue	BRCA1	10	c.2388_2389del	p.Thr796fs	Frameshift
9	Tumor tissue	BRCA1	10	c.3868dupA	p.C1291Mfs∗4	Frameshift
10	Tumor tissue	BRCA1	10	c.1504_1508del	p.Leu502fs	Frameshift
11	Peripheral blood	BRCA1	10	c.2889_2890del	p.G964Tfs∗6	Frameshift
12	Tumor tissue	BRCA1	10	c.1276del	p.S426Qfs∗4	Frameshift
13	Tumor tissue	BRCA1	10	c.2302delA	p.Ser768Valfs∗24	Frameshift
14	Tumor tissue	BRCA1	12	c.4357+1G>A	/	Splicing mutation
15	Tumor tissue	BRCA1	13	c.4485-2A>C	/	Splicing mutation
16	Tumor tissue	BRCA1	14	c.4566G>C	p.Tyr1522Ter	Nonsense
17	Tumor tissue	BRCA1	15	c.4756G>T	p.Glu1586Ter	Nonsense
18	Tumor tissue	BRCA1	23	c.5468-2A>G	/	Splicing mutation
19	Tumor tissue	BRCA1	23	c.5511_5524del	p.W1837Cfs∗38	Deletion
20	Tumor tissue	BRCA2	9	c.755_758del	p.Asp252Valfs∗24	Frameshift
21	Tumor tissue	BRCA2	11	c.3109C>T	p.Gln1037Ter	Nonsense
22	Peripheral blood	BRCA2	11	c.3109C>T	p.Gln1037Ter	Nonsense
23	Tumor tissue	BRCA2	11	c.C3523T	p.Gln1175Ter	Nonsense
24	Tumor tissue	BRCA2	11	c.5576_5579delTTAA	p.Idel1859Lysfs	Frameshift
25	Tumor tissue	BRCA2	11	c.5164_5165delAG	p.Ser1722Tyrfs	Frameshift
26	Tumor tissue	BRCA2	11	c.2176delG	p.V726Ffs∗4	Frameshift
27	Peripheral blood	BRCA2	22	c.8915delT	p.leu2972Cysfs∗4	Deletion