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Effect of the PGC-1α inhibitor on the analgesic effect of RTA-408. The analgesic effect of RTA-408 in CCI mice was completely inhibited by the PGC-1α inhibitor SR-18292. Two-way ANOVA with repeated measures was performed, followed by the Bonferroni post hoc test (∗∗∗P < 0.001 compared with the sham+vehicle group, ###P < 0.001 compared with the CCI+RTA+SR group, n = 5 per group).
